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Determination of Pefloxacin in Serum and Pharmaceutical Forms by Derivative Spectrophotometry
dc.creator | Đurđević, P. | |
dc.creator | Jelikic-Stankov, M. | |
dc.creator | Milićević, Zoran | |
dc.date.accessioned | 2019-04-04T15:50:12Z | |
dc.date.available | 2019-04-04T15:50:12Z | |
dc.date.issued | 1997 | |
dc.identifier.issn | 0026-3672 | |
dc.identifier.uri | https://plantarum.izbis.bg.ac.rs/handle/123456789/6 | |
dc.description.abstract | A method for the direct determination of pefloxacin in serum and pharmaceutical forms (tablets and ampoules) has been developed, based on the use of second-order derivative ultraviolet spectra. Spectrophotometric assay of pefloxacin in tablets and ampoules was carried out in 0.1 mol/L NaOH, while in serum it was performed in 0.1 mol/L NaOH with the addition of sodium dodecylsulfate, in 337-347 nm wavelength range. Linear calibration curves were obtained in the concentration ranges 2-30μg/mL pefloxacin for tablets and ampoules and 0.12-5μg/ mL for serum samples. Relative error of determination, as criterion for accuracy, was less than 1%, while the precision was better than 4ng/ml. The minimum detectable concentration of pefloxacin in serum was 15ng/mL. | en |
dc.publisher | Springer Verlag | |
dc.rights | restrictedAccess | |
dc.source | Mikrochimica Acta | |
dc.subject | Derivative spectrophotometry | en |
dc.subject | Pefloxacin | en |
dc.subject | Pharmaceutical forms | en |
dc.subject | Serum | en |
dc.title | Determination of Pefloxacin in Serum and Pharmaceutical Forms by Derivative Spectrophotometry | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 206 | |
dc.citation.issue | 3 | |
dc.citation.other | 126(3): 203-206 | |
dc.citation.spage | 203 | |
dc.citation.volume | 126 | |
dc.type.version | publishedVersion | |
dc.identifier.doi | 10.1007/BF01242321 | |
dc.identifier.scopus | 2-s2.0-0012501004 | |
dc.identifier.wos | A1997XG63500003 |