Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
Нема приказа
Аутори
Stikić, RadmilaMilincić, Danijel
Kostić, Aleksandar
Jovanović, Zorica
Gašić, Uroš
Tešić, Živoslav
Djordjević, Nataša
Savić, Sladjana
Czekus, Borisz
Pešić, Mirjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
BACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colo...rectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.
Кључне речи:
antioxidant activity / colon cancer / cytotoxic activity / flavonoids / phenolic acids / quinoa seedИзвор:
Cereal Chemistry, 2020, 97, 3, 626-633Издавач:
- Wiley
Финансирање / пројекти:
- Савремени биотехнолошки приступ решавања проблема суше у пољопривреди Србије (RS-MESTD-Technological Development (TD or TR)-31005)
- Испитивање могућности коришћења контаминираних вода за гајење алтернативних, здравствено безбедних жита (RS-MESTD-Technological Development (TD or TR)-31006)
- Коришћење биљних извора протеина, дијеталних влакана и антиоксиданаса у производњи хране (RS-MESTD-Technological Development (TD or TR)-31069)
- Корелација структуре и особина природних и синтетичких молекула и њихових комплекса са металима (RS-MESTD-Basic Research (BR or ON)-172017)
- Физиолошка, хемијска и молекуларна анализа диверзитета одабраних ретких и угрожених биљних врста у циљу еx ситу заштите и продукције биолошки активних једињења (RS-MESTD-Basic Research (BR or ON)-173024)
- Молекуларно физиолошки биомониторинг аеробних организама заснован на одређивању биохемијских биомаркера оксидационог стреса (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1002/cche.10278
ISSN: 0009-0352
PubMed: 000521447000001
Scopus: 2-s2.0-85082187869
Институција/група
IZBISTY - JOUR AU - Stikić, Radmila AU - Milincić, Danijel AU - Kostić, Aleksandar AU - Jovanović, Zorica AU - Gašić, Uroš AU - Tešić, Živoslav AU - Djordjević, Nataša AU - Savić, Sladjana AU - Czekus, Borisz AU - Pešić, Mirjana PY - 2020 UR - https://plantarum.izbis.bg.ac.rs/handle/123456789/853 AB - BACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds. PB - Wiley T2 - Cereal Chemistry T1 - Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars EP - 633 IS - 3 SP - 626 VL - 97 DO - 10.1002/cche.10278 ER -
@article{ author = "Stikić, Radmila and Milincić, Danijel and Kostić, Aleksandar and Jovanović, Zorica and Gašić, Uroš and Tešić, Živoslav and Djordjević, Nataša and Savić, Sladjana and Czekus, Borisz and Pešić, Mirjana", year = "2020", abstract = "BACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.", publisher = "Wiley", journal = "Cereal Chemistry", title = "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars", pages = "633-626", number = "3", volume = "97", doi = "10.1002/cche.10278" }
Stikić, R., Milincić, D., Kostić, A., Jovanović, Z., Gašić, U., Tešić, Ž., Djordjević, N., Savić, S., Czekus, B.,& Pešić, M.. (2020). Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry Wiley., 97(3), 626-633. https://doi.org/10.1002/cche.10278
Stikić R, Milincić D, Kostić A, Jovanović Z, Gašić U, Tešić Ž, Djordjević N, Savić S, Czekus B, Pešić M. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry. 2020;97(3):626-633. doi:10.1002/cche.10278 .
Stikić, Radmila, Milincić, Danijel, Kostić, Aleksandar, Jovanović, Zorica, Gašić, Uroš, Tešić, Živoslav, Djordjević, Nataša, Savić, Sladjana, Czekus, Borisz, Pešić, Mirjana, "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars" in Cereal Chemistry, 97, no. 3 (2020):626-633, https://doi.org/10.1002/cche.10278 . .