Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin
Само за регистроване кориснике
2015
Аутори
Milisavljević, M.Živković, Svetlana

Pekmezović, M.
Stanković, N.
Vojnović, S.

Vasiljević, B.

Senerović, L.

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
AimsThe aim of this study was to address the toxicity of recently described polyene macrolide 32, 33-didehydroroflamycoin (DDHR) on a wide range of fungal pathogens and its potential to control plant fungal diseases. Methods and ResultsThe antifungal activity of DDHR invitro was examined against common human and plant pathogenic fungi using a broth microdilution assay and a disk diffusion assay. Minimum inhibitory concentrations ranged from 125 to 35gml(-1). A radial growth inhibition assay showed that DDHR inhibited mycelia growth, inducing mycelial necrosis and affecting sporulation. During the invivo assay on apple fruits administration of DDHR 1h before fungal inoculation inhibited spreading of the infection. Importantly, DDHR exhibited no phytotoxic effects on the model plant, Capsicum annum, verified by the plant growth rate and chlorophyll content. ConclusionsDDHR inhibits growth of various plant pathogens invitro with the strongest activity against Alternaria alternata, Colleto...trichum acutatum and Penicillium expansum, and protects apple fruits from decay. Significance and Impact of the StudyThis is the first report of the inhibitory effect of DDHR on important pathogenic fungal isolates. DDHR could be a good scaffold for developing new antifungal agents for fruit and vegetable protection.
Кључне речи:
32-33-didehydroroflamycoin / fungi / human pathogens / plant pathogens / polyene macrolideИзвор:
Journal of Applied Microbiology, 2015, 118, 6, 1426-1434Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-173048)
- Молекуларни механизми одговора биљака на абиотички стрес-улога транскрипционих фактора и малих РНК и анализа генетичког диверзитета биљних култура од интереса за пољопривреду и биотехнологију (RS-173005)
- Разрада интегрисаног управљања и примене савремених принципа сузбијања штетних организама у заштити биља (RS-31018)
DOI: 10.1111/jam.12811
ISSN: 1364-5072
PubMed: 25810243
WoS: 000354570600017
Scopus: 2-s2.0-84929509136
Институција/група
IZBISTY - JOUR AU - Milisavljević, M. AU - Živković, Svetlana AU - Pekmezović, M. AU - Stanković, N. AU - Vojnović, S. AU - Vasiljević, B. AU - Senerović, L. PY - 2015 UR - https://plantarum.izbis.bg.ac.rs/handle/123456789/378 AB - AimsThe aim of this study was to address the toxicity of recently described polyene macrolide 32, 33-didehydroroflamycoin (DDHR) on a wide range of fungal pathogens and its potential to control plant fungal diseases. Methods and ResultsThe antifungal activity of DDHR invitro was examined against common human and plant pathogenic fungi using a broth microdilution assay and a disk diffusion assay. Minimum inhibitory concentrations ranged from 125 to 35gml(-1). A radial growth inhibition assay showed that DDHR inhibited mycelia growth, inducing mycelial necrosis and affecting sporulation. During the invivo assay on apple fruits administration of DDHR 1h before fungal inoculation inhibited spreading of the infection. Importantly, DDHR exhibited no phytotoxic effects on the model plant, Capsicum annum, verified by the plant growth rate and chlorophyll content. ConclusionsDDHR inhibits growth of various plant pathogens invitro with the strongest activity against Alternaria alternata, Colletotrichum acutatum and Penicillium expansum, and protects apple fruits from decay. Significance and Impact of the StudyThis is the first report of the inhibitory effect of DDHR on important pathogenic fungal isolates. DDHR could be a good scaffold for developing new antifungal agents for fruit and vegetable protection. PB - Wiley, Hoboken T2 - Journal of Applied Microbiology T1 - Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin EP - 1434 IS - 6 SP - 1426 VL - 118 DO - 10.1111/jam.12811 ER -
@article{ author = "Milisavljević, M. and Živković, Svetlana and Pekmezović, M. and Stanković, N. and Vojnović, S. and Vasiljević, B. and Senerović, L.", year = "2015", abstract = "AimsThe aim of this study was to address the toxicity of recently described polyene macrolide 32, 33-didehydroroflamycoin (DDHR) on a wide range of fungal pathogens and its potential to control plant fungal diseases. Methods and ResultsThe antifungal activity of DDHR invitro was examined against common human and plant pathogenic fungi using a broth microdilution assay and a disk diffusion assay. Minimum inhibitory concentrations ranged from 125 to 35gml(-1). A radial growth inhibition assay showed that DDHR inhibited mycelia growth, inducing mycelial necrosis and affecting sporulation. During the invivo assay on apple fruits administration of DDHR 1h before fungal inoculation inhibited spreading of the infection. Importantly, DDHR exhibited no phytotoxic effects on the model plant, Capsicum annum, verified by the plant growth rate and chlorophyll content. ConclusionsDDHR inhibits growth of various plant pathogens invitro with the strongest activity against Alternaria alternata, Colletotrichum acutatum and Penicillium expansum, and protects apple fruits from decay. Significance and Impact of the StudyThis is the first report of the inhibitory effect of DDHR on important pathogenic fungal isolates. DDHR could be a good scaffold for developing new antifungal agents for fruit and vegetable protection.", publisher = "Wiley, Hoboken", journal = "Journal of Applied Microbiology", title = "Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin", pages = "1434-1426", number = "6", volume = "118", doi = "10.1111/jam.12811" }
Milisavljević, M., Živković, S., Pekmezović, M., Stanković, N., Vojnović, S., Vasiljević, B.,& Senerović, L.. (2015). Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin. in Journal of Applied Microbiology Wiley, Hoboken., 118(6), 1426-1434. https://doi.org/10.1111/jam.12811
Milisavljević M, Živković S, Pekmezović M, Stanković N, Vojnović S, Vasiljević B, Senerović L. Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin. in Journal of Applied Microbiology. 2015;118(6):1426-1434. doi:10.1111/jam.12811 .
Milisavljević, M., Živković, Svetlana, Pekmezović, M., Stanković, N., Vojnović, S., Vasiljević, B., Senerović, L., "Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin" in Journal of Applied Microbiology, 118, no. 6 (2015):1426-1434, https://doi.org/10.1111/jam.12811 . .