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Determination of Pefloxacin in Serum and Pharmaceutical Forms by Derivative Spectrophotometry

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1997
Authors
Đurđević, P.
Jelikic-Stankov, M.
Milićević, Zoran
article (publishedVersion)
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Abstract
A method for the direct determination of pefloxacin in serum and pharmaceutical forms (tablets and ampoules) has been developed, based on the use of second-order derivative ultraviolet spectra. Spectrophotometric assay of pefloxacin in tablets and ampoules was carried out in 0.1 mol/L NaOH, while in serum it was performed in 0.1 mol/L NaOH with the addition of sodium dodecylsulfate, in 337-347 nm wavelength range. Linear calibration curves were obtained in the concentration ranges 2-30μg/mL pefloxacin for tablets and ampoules and 0.12-5μg/ mL for serum samples. Relative error of determination, as criterion for accuracy, was less than 1%, while the precision was better than 4ng/ml. The minimum detectable concentration of pefloxacin in serum was 15ng/mL.
Keywords:
Derivative spectrophotometry / Pefloxacin / Pharmaceutical forms / Serum
Source:
Mikrochimica Acta, 1997, 126, 3, 203-206
Publisher:
  • Springer Verlag

DOI: 10.1007/BF01242321

ISSN: 0026-3672

WoS: A1997XG63500003

Scopus: 2-s2.0-0012501004
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URI
https://plantarum.izbis.bg.ac.rs/handle/123456789/6
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