Development and validation of LC-MS/MS method for the citrinin determination in red rice
Authors
Vuković, GoricaĐukić, Marina
Bursić, Vojislava
Stojanović Petrović, Aleksandra
Kuzmanović, Slobodan
Starović, Mira
Article (Published version)
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Show full item recordAbstract
The liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the citrinin (CIN) determination in red rice was developed. The mycotoxin was extracted from red rice using anetonitrile/water/acetic acid mixture followed by the clean-up step on Captiva EMR cartridges. The developed method was validated according to the Commission Regulation No. 401/2006/EC. The validation data were evaluated in terms of recoveries, reproducibility, limits of quantification (LOQ), limit of detection (LOD), specificity, linearity and matrix effects for CIN in matrix using 13C20-OTA as an internal standard. The obtained method performance parameters indicate that the method is suitable for the CIN routine analysis.
Keywords:
citrinin / validation / LC-MS/MSSource:
Journal of Agronomy, Technology and Engineering Management, 2019, 2, 1, 192-199Publisher:
- University Business Academy, Faculty of Economics and Engineering Management, Novi Sad, Serbia
Funding / projects:
- Development of integrated approach in plant protection for control harmful organisms (RS-MESTD-Technological Development (TD or TR)-31018)
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IZBISTY - JOUR AU - Vuković, Gorica AU - Đukić, Marina AU - Bursić, Vojislava AU - Stojanović Petrović, Aleksandra AU - Kuzmanović, Slobodan AU - Starović, Mira PY - 2019 UR - https://plantarum.izbis.bg.ac.rs/handle/123456789/1007 AB - The liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the citrinin (CIN) determination in red rice was developed. The mycotoxin was extracted from red rice using anetonitrile/water/acetic acid mixture followed by the clean-up step on Captiva EMR cartridges. The developed method was validated according to the Commission Regulation No. 401/2006/EC. The validation data were evaluated in terms of recoveries, reproducibility, limits of quantification (LOQ), limit of detection (LOD), specificity, linearity and matrix effects for CIN in matrix using 13C20-OTA as an internal standard. The obtained method performance parameters indicate that the method is suitable for the CIN routine analysis. PB - University Business Academy, Faculty of Economics and Engineering Management, Novi Sad, Serbia T2 - Journal of Agronomy, Technology and Engineering Management T1 - Development and validation of LC-MS/MS method for the citrinin determination in red rice EP - 199 IS - 1 SP - 192 VL - 2 ER -
@article{ author = "Vuković, Gorica and Đukić, Marina and Bursić, Vojislava and Stojanović Petrović, Aleksandra and Kuzmanović, Slobodan and Starović, Mira", year = "2019", abstract = "The liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the citrinin (CIN) determination in red rice was developed. The mycotoxin was extracted from red rice using anetonitrile/water/acetic acid mixture followed by the clean-up step on Captiva EMR cartridges. The developed method was validated according to the Commission Regulation No. 401/2006/EC. The validation data were evaluated in terms of recoveries, reproducibility, limits of quantification (LOQ), limit of detection (LOD), specificity, linearity and matrix effects for CIN in matrix using 13C20-OTA as an internal standard. The obtained method performance parameters indicate that the method is suitable for the CIN routine analysis.", publisher = "University Business Academy, Faculty of Economics and Engineering Management, Novi Sad, Serbia", journal = "Journal of Agronomy, Technology and Engineering Management", title = "Development and validation of LC-MS/MS method for the citrinin determination in red rice", pages = "199-192", number = "1", volume = "2" }
Vuković, G., Đukić, M., Bursić, V., Stojanović Petrović, A., Kuzmanović, S.,& Starović, M.. (2019). Development and validation of LC-MS/MS method for the citrinin determination in red rice. in Journal of Agronomy, Technology and Engineering Management University Business Academy, Faculty of Economics and Engineering Management, Novi Sad, Serbia., 2(1), 192-199.
Vuković G, Đukić M, Bursić V, Stojanović Petrović A, Kuzmanović S, Starović M. Development and validation of LC-MS/MS method for the citrinin determination in red rice. in Journal of Agronomy, Technology and Engineering Management. 2019;2(1):192-199..
Vuković, Gorica, Đukić, Marina, Bursić, Vojislava, Stojanović Petrović, Aleksandra, Kuzmanović, Slobodan, Starović, Mira, "Development and validation of LC-MS/MS method for the citrinin determination in red rice" in Journal of Agronomy, Technology and Engineering Management, 2, no. 1 (2019):192-199.